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• Helps Gently Restore and Maintain Microbial Balance and Diversity

• Reduces Gas, Bloating, and Food Intolerance

• Improves Occasional Constipation and Diarrhea

• Maintains GI Barrier Integrity

Ortho Spore Complete is a spore-based, broad-spectrum probiotic formula designed to maintain diversity and balance in the gut microbiota and support gastrointestinal health after SIBO.

Bacillus coagulans (strains MTCC 5856 [LactoSpore®] and SNZ 1969)

Bacillus coagulans supports a balanced microbiota by having antagonistic effects against unwanted organisms and supporting healthy commensal microbes. In an in vitro mechanism study, B. coagulans demonstrated antagonistic action against a variety of undesirable organisms. B. coagulans supplementation at a dose of 1 billion CFU/day for 28 days GASTROINTESTINAL SUPPORT These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. in adults over age 65 increased fecal concentrations of the commensal F. prausnitzii from baseline compared to placebo; fecal Bacillus spp. also increased in this population. B. coagulans supports GI health. B. coagulans MTCC 5856 given at a dose of 2 billion CFU/day reduced symptoms related to occasional diarrhea in adults with GI disturbance after 90 days of supplementation. Another study found B. coagulans MTCC 5856 was safe when given at the 2 billion CFU dose for 30 days in a group of healthy subjects. Symptoms of occasional GI discomfort significantly improved with supplementation of a combination of Bacillus probiotic strains at total dose of 2 billion CFU/day (i.e., B. coagulans SNZ 1969, B. clausii SNZ 1971 and B. subtilis SNZ 1972) for 30 days in 60 adults with occasional GI discomfort.

Bacillus clausii B106

Bacillus clausii supports GI health, a balanced intestinal microbiota, and immune health. B. clausii at a dose of 2 billion CFU twice per day for 10 days has demonstrated significant effectiveness in adults with occasional diarrhea. B. clausii has significantly reduced the duration of occasional diarrhea and decreased stool frequency in a meta-analysis of 1,298 children with dosages ranging from 1 billion CFU twice per day to 4 billion CFU/day. B. clausii has also shown benefit as a probiotic in subjects with small intestinal bacterial overgrowth via normalization of glucose breath test when given at a dose of 2 billion CFU, three times per day for one month in an open-label study. B. clausii at an oral dose of 2 billion CFU twice per day was shown to maintain healthy respiratory function after 90 days in a study of 80 participants. A recent candidate genome analysis performed on the B. clausii B106 strain found genes for several beneficial probiotic properties of the strain (i.e., genes responsible for GI survival and adaptation, adhesion, vitamin synthesis [i.e., riboflavin, folate, biotin], bacteriocins production, stress resistance, etc.). Genes were also present for sporulation, suggesting that B. clausii B106 is a resilient and stable probiotic strain.

Bacillus subtilis (strains HU58 and HS43)

Bacillus subtilis has been shown to relieve GI distress in patients. B. subtilis supplementation of 1-3 billion CFU alongside motility stimulating agents was effective for GI symptom relief at four weeks. Supplementation with B. subtilis HU58 plus B. coagulans SC208 at a total dose of 3 billion CFU/day significantly improved stool consistency and GI symptoms (i.e., occasional abdominal pain, bloating, flatulence) in patients with occasional diarrhea compared to placebo.

Directions

2 capsules per day or as recommended by your health care professional.

Does Not Contain

Wheat, gluten, soy, corn, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.

Cautions

If you are pregnant or nursing, consult your physician before taking this product.